Clinical Manifestations, Treatment and Outcomes of Multisystem Inflammatory Syndrome in Children (MIS-C) Associated with COVID-19: A Single-Center Experience from Iran | ||
| Journal of Integrated Maternal and Pediatric Care | ||
| Volume 8, Issue 2, June 2026, Pages 108-124 PDF (681.86 K) | ||
| Document Type: Original Article | ||
| DOI: 10.18502/wjpn.v8i2.22107 | ||
| Authors | ||
| Farzad Ferdosian1, 2; Mohammad Emad Sharifi3, 4; Mehran Karimi1, 2; Naeimeh Naserzadeh1, 2; Zahra Nafei1, 2; Niloufar Vaziri Bozorg5; Shekoofeh Savabieh* 2, 4 | ||
| 1Children Growth Disorder Research Center, Comprehensive Research Institute for Maternal and Child Health, Shahid Sadoughi University of Medical Sciences, Yazd, Iran | ||
| 2Department of Pediatrics, School of Medicine, Shahid Sadoughi University of Medical Sciences, Yazd, Iran | ||
| 3School of Dentistry, Tehran University of Medical Sciences, Tehran, Iran | ||
| 4Mother and Newborn Health Research Center, Comprehensive Research Institute for Maternal and Child Health, Shahid Sadoughi University of Medical Sciences, Yazd, Iran | ||
| 5School of Medicine, Shahid Sadoughi University of Medical Sciences, Yazd, Iran | ||
| Abstract | ||
| Background: Multisystem inflammatory syndrome in children (MIS-C) is a documented complication arising from SARS-CoV-2 infection. Even pediatric patients who present with mild initial COVID-19 symptoms may subsequently experience severe morbidity or mortality due to MIS-C; therefore, early identification and prompt clinical management are essential for achieving favorable outcomes. This study aimed to assess the clinical characteristics, therapeutic strategies, and patient outcomes among children diagnosed with MIS-C in Yazd, Iran. Methods: This study included all pediatric patients admitted to Shahid Sadoughi Hospital in Yazd, Iran, who presented with either suspected or confirmed MIS-C between March 2020 and March 2021. Comprehensive data were extracted from medical records, including demographics, clinical symptoms, laboratory biomarkers, imaging results, and treatment modalities. Results: The study included 40 children (52.5% males, 47.5% females, median age 7.3 years). Fever was the predominant symptom (87.5%), followed by gastrointestinal complaints (57.5%) and mucocutaneous abnormalities (20%). The digestive, respiratory, and neurological systems were most frequently involved. Hospitalisation lasted 1–7 days in 75% and 8–14 days in 22.5% of patients. Disease severity was severe in 25%, moderate in 47.5%, and mild in 27.5%. Remdesivir (40%), corticosteroids (52.5%), and intravenous immunoglobulin (47.5%) were used as treatment. Notably, the overall mortality rate was 22.5% (9/40), substantially higher than the rates reported in most international studies. Conclusion: This elevated mortality underscores the urgent need for enhanced early detection, rapid referral systems, and timely immunomodulatory therapy. Previous studies have reported that COVID-19 vaccination is associated with a reduced incidence of MIS-C. | ||
| Keywords | ||
| Multisystem inflammatory syndrome in children (MIS-C); COVID-19; SARS-CoV-2; Pediatrics; Mortality; Iran | ||
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